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Considered a conditionally essential amino acid, L-glutamine comprises up to 60 percent of free-from amino acids circulating in muscle tissue and is critical for muscle recoveryafter exercise. For decades, it was thought to have a lower dietary adequacy than other essential amino acids such as methionine (the breakdown product of glutamine), histidine, and leucine, despite the fact that they were all considered essential. L-Glutamine is present in both low-fat and low-meat diets, and some have suggested that protein alone could be adequate for the repair of muscle proteins after exercise. However, L-Glutamine is often depleted following prolonged endurance exercise, and its level is associated with increased risk of acute cardiogenic shock. L-glutamine is also found in large amounts in the blood of athletes who participate in high-intensity, intermittent exercise; this is of particular concern, because of the potential for the amino acid to promote tissue damage during exercise. Despite its known importance for muscle repair and restoration, current nutritional recommendations for patients with type 1 diabetes are that the daily intake of L-Glutamine should only be limited to 60 mg. This is an amount that is insufficient to prevent loss of the amino acid, and it is thought that the additional requirements for L-Glutamine supplementation could lead to a loss of muscle function. With increasing emphasis on promoting recovery and preventing muscle damage in patients with type 1 diabetes, it is not surprising that L-glutamine supplementation is increasingly being considered as a possible therapeutic strategy. The goal of this clinical trial was to assess the effects of L-Glutamine supplementation in healthy male subjects with type 1 diabetes for 12 weeks. Twenty-four hours prior to testing, all subjects were required to complete an 8-item questionnaire and then a post-exercise metabolic panel was administered to ensure that adequate amounts of other macronutrients, e.g., protein, were present to meet their daily energy needs. All subjects completed a 4-day diet recall before randomization. After 12 weeks, the study protocol was altered to exclude the subjects with impaired glucose tolerance and their primary care providers. The subjects with impaired glucose tolerance were excluded from the protocol. Subjects underwent a randomized, double-blind, placebo-controlled, two part, crossover design. After the first 3 days of the study, subjects were randomly assigned into three groups. The first group ingested a daily supplement containing 1.0 g of L-Glutamine (as a liquid), 2.0 g of L-Glutamine as a powder, or a single dose of 250 mg. L-Glut Similar articles: